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IMPORTANT: Healthcare provider enrollment and participation in the Provider Locator is voluntary and free of charge and, along with the provider-specific information in the Provider Locator, is based solely on healthcare provider responses. Inclusion in the Provider Locator does not imply a referral, recommendation, or endorsement by Alkermes, Inc. We recommend that you research the credentials, qualifications, and experience of each provider before confirming an appointment. Alkermes shall in no event be liable to you or to anyone for any decision made or action taken by you in the reliance on this information.

VIVITROL is not right for everyone. There are significant risks from VIVITROL treatment, including risk of opioid overdose, severe reaction at the injection site, and sudden opioid withdrawal.

Important Safety Information

VIVITROL ® can cause serious side effects, including:

• Risk of opioid overdose.
  • VIVITROL blocks the effects of opioids, such as heroin or opioid pain medicines. Do not try to overcome this blocking effect by taking large amounts of opioids—this can lead to serious injury, coma, or death.
  • After you receive a dose of VIVITROL, its blocking effect slowly decreases and completely goes away over time. If you have used opioid street drugs or opioid-containing medicines in the past, using opioids in amounts that you used before treatment with VIVITROL can lead to overdose and death. You may also be more sensitive to the effects of lower amounts of opioids:
    • after you have gone through detoxification
    • when your next VIVITROL dose is due
    • if you miss a dose of VIVITROL
    • after you stop VIVITROL treatment

    Do not receive VIVITROL if you:

    • are using or have a physical dependence on opioid-containing medicines or opioid street drugs, such as heroin. To test for a physical dependence on opioid-containing medicines or street drugs, your healthcare provider may give you a small injection of a medicine called naloxone. This is called a naloxone challenge test. If you get symptoms of opioid withdrawal after the naloxone challenge test, do not start treatment with VIVITROL at that time. Your healthcare provider may repeat the test after you have stopped using opioids to see whether it is safe to start VIVITROL.
    • are having opioid withdrawal symptoms which may include anxiety, sleeplessness, yawning, fever, sweating, teary eyes, runny nose, goose bumps, shakiness, hot or cold flushes, muscle aches, muscle twitches, restlessness, nausea and vomiting, diarrhea, or stomach cramps.
    • are allergic to naltrexone or any of the ingredients in VIVITROL or the liquid used to mix VIVITROL (diluent).

    Before you receive VIVITROL, tell your healthcare provider if you:

    • have liver problems, use or abuse street drugs, have hemophilia or other bleeding problems, have kidney problems, or have any other medical conditions.
    • are pregnant or plan to become pregnant. It is not known if VIVITROL will harm your unborn baby.
    • are breastfeeding. It is not known if VIVITROL passes into your milk, and if it can harm your baby. Naltrexone, the active ingredient in VIVITROL, is the same active ingredient in tablets taken by mouth that contain naltrexone. Naltrexone from tablets passes into breast milk. Talk to your healthcare provider about whether you will breastfeed or take VIVITROL. You should not do both.

    Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take any opioid-containing medicines for pain, cough or colds, or diarrhea.

    If you are being treated for alcohol dependence but also use or are addicted to opioid-containing medicines or opioid street drugs, it is important that you tell your healthcare provider before starting VIVITROL to avoid having sudden opioid withdrawal symptoms when you start VIVITROL treatment.

    What should I avoid while receiving VIVITROL?
    Do not drive a car, operate machinery, or do other dangerous activities until you know how VIVITROL affects you. VIVITROL may make you feel dizzy and sleepy.

    VIVITROL can cause other serious side effects, including:

    • Depressed mood, which can sometimes lead to suicide, or suicidal thoughts, and suicidal behavior. You, a family member, or the people closest to you should call your healthcare provider right away if you have these thoughts or symptoms especially if they are new, worse, or worry you.
    • Pneumonia caused by an allergic reaction. If this type of pneumonia happens to you, you may need to be treated in the hospital.
    • Serious allergic reactions that can happen during or soon after an injection of VIVITROL. Tell your healthcare provider or get medical help right away if you have any of these symptoms, skin rash; swelling of your face, eyes, mouth, or tongue; trouble breathing or wheezing; chest pain; feeling dizzy or faint.

    Common side effects of VIVITROL may include nausea, sleepiness, headache, dizziness, vomiting, decreased appetite, painful joints, muscle cramps, cold symptoms, trouble sleeping, toothache.

    These are not all the side effects of VIVITROL. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. You are encouraged to report all side effects to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

    Indications:

    VIVITROL is a prescription injectable medicine used to:

    • Treat alcohol dependence. You should stop drinking before starting VIVITROL.
    • Prevent relapse to opioid dependence, after opioid detoxification.

    You must stop taking opioids before you start receiving VIVITROL. To be effective, VIVITROL must be used with other alcohol or drug recovery programs such as counseling.

    VIVITROL may not work for everyone. It is not known if VIVITROL is safe and effective in children.

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    IMPORTANT: Healthcare provider enrollment and participation in the Provider Locator is voluntary and free of charge and, along with the provider-specific information in the Provider Locator, is based solely on healthcare provider responses. Inclusion in the Provider Locator does not imply a referral, recommendation, or endorsement by Alkermes, Inc. We recommend that you research the credentials, qualifications, and experience of each provider before confirming an appointment. Alkermes shall in no event be liable to you or to anyone for any decision made or action taken by you in the reliance on this information.

    LEARN ABOUT POSSIBLE SAVINGS ON YOUR VIVITROL PRESCRIPTION

    Through the VIVITROL ® Co-pay Savings Program, eligible patients can reduce their out-of-pocket costs.*

    GETTING YOUR PRESCRIPTION

    Resources are available to help you prepare for your VIVITROL injection.

    VIVITROL is not right for everyone. There are significant risks from VIVITROL treatment, including risk of opioid overdose, severe reactions at the injection site, sudden opioid withdrawal, liver damage or hepatitis.

    Talk to your healthcare provider about naloxone, a medicine that is available to patients for the emergency treatment of an opioid overdose.

    Call 911 or get emergency medical help right away in all cases of known or suspected opioid overdose, even if naloxone is administered.

    If you are being treated for alcohol dependence but also use or are addicted to opioid-containing medicines or opioid street drugs, it is important that you tell your healthcare provider before starting VIVITROL to avoid having sudden opioid withdrawal symptoms when you start VIVITROL treatment.

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    *Terms and Conditions

    Eligible patients who have commercial insurance or no insurance may pay as little as $0 per prescription of VIVITROL. Maximum savings per prescription is $500 up to 12 prescriptions per calendar year, with maximum savings up to $6,000 per calendar year. Patients' out-of-pocket expenses may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Additional terms and conditions apply. Please see www.vivitrolcopayterms.com for full VIVITROL Co-pay Program Terms and Conditions.

    Important safety
    information

    Important safety information
    

    VIVITROL ® can cause serious side effects, including:

    • Risk of opioid overdose.
      • VIVITROL blocks the effects of opioids, such as heroin or opioid pain medicines. Do not try to overcome this blocking effect by taking large amounts of opioids—this can lead to serious injury, coma, or death.
      • After you receive a dose of VIVITROL, its blocking effect slowly decreases and completely goes away over time. If you have used opioid street drugs or opioid-containing medicines in the past, using opioids in amounts that you used before treatment with VIVITROL can lead to overdose and death. You may also be more sensitive to the effects of lower amounts of opioids:
        • after you have gone through detoxification
        • when your next VIVITROL dose is due
        • if you miss a dose of VIVITROL
        • after you stop VIVITROL treatment

        Do not receive VIVITROL if you:

        • are using or have a physical dependence on opioid-containing medicines or opioid street drugs, such as heroin. To test for a physical dependence on opioid-containing medicines or street drugs, your healthcare provider may give you a small injection of a medicine called naloxone. This is called a naloxone challenge test. If you get symptoms of opioid withdrawal after the naloxone challenge test, do not start treatment with VIVITROL at that time. Your healthcare provider may repeat the test after you have stopped using opioids to see whether it is safe to start VIVITROL.
        • are having opioid withdrawal symptoms which may include anxiety, sleeplessness, yawning, fever, sweating, teary eyes, runny nose, goose bumps, shakiness, hot or cold flushes, muscle aches, muscle twitches, restlessness, nausea and vomiting, diarrhea, or stomach cramps.
        • are allergic to naltrexone or any of the ingredients in VIVITROL or the liquid used to mix VIVITROL (diluent).

        Before you receive VIVITROL, tell your healthcare provider if you:

        • have liver problems, use or abuse street drugs, have hemophilia or other bleeding problems, have kidney problems, or have any other medical conditions.
        • are pregnant or plan to become pregnant. It is not known if VIVITROL will harm your unborn baby.
        • are breastfeeding. It is not known if VIVITROL passes into your milk, and if it can harm your baby. Naltrexone, the active ingredient in VIVITROL, is the same active ingredient in tablets taken by mouth that contain naltrexone. Naltrexone from tablets passes into breast milk. Talk to your healthcare provider about whether you will breastfeed or take VIVITROL. You should not do both.

        Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take any opioid-containing medicines for pain, cough or colds, or diarrhea.

        If you are being treated for alcohol dependence but also use or are addicted to opioid-containing medicines or opioid street drugs, it is important that you tell your healthcare provider before starting VIVITROL to avoid having sudden opioid withdrawal symptoms when you start VIVITROL treatment.

        What should I avoid while receiving VIVITROL?
        Do not drive a car, operate machinery, or do other dangerous activities until you know how VIVITROL affects you. VIVITROL may make you feel dizzy and sleepy.

        VIVITROL can cause other serious side effects, including:

        • Depressed mood, which can sometimes lead to suicide, or suicidal thoughts, and suicidal behavior. You, a family member, or the people closest to you should call your healthcare provider right away if you have these thoughts or symptoms especially if they are new, worse, or worry you.
        • Pneumonia caused by an allergic reaction. If this type of pneumonia happens to you, you may need to be treated in the hospital.
        • Serious allergic reactions that can happen during or soon after an injection of VIVITROL. Tell your healthcare provider or get medical help right away if you have any of these symptoms, skin rash; swelling of your face, eyes, mouth, or tongue; trouble breathing or wheezing; chest pain; feeling dizzy or faint.

        Common side effects of VIVITROL may include nausea, sleepiness, headache, dizziness, vomiting, decreased appetite, painful joints, muscle cramps, cold symptoms, trouble sleeping, toothache.

        These are not all the side effects of VIVITROL. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. You are encouraged to report all side effects to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

        Indications:

        VIVITROL is a prescription injectable medicine used to:

        • Treat alcohol dependence. You should stop drinking before starting VIVITROL.
        • Prevent relapse to opioid dependence, after opioid detoxification.

        You must stop taking opioids before you start receiving VIVITROL. To be effective, VIVITROL must be used with other alcohol or drug recovery programs such as counseling.

        VIVITROL may not work for everyone. It is not known if VIVITROL is safe and effective in children.

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        *Terms and Conditions

        Eligible patients who have commercial insurance or no insurance may pay as little as $0 per prescription of VIVITROL. Maximum savings per prescription is $500 up to 12 prescriptions per calendar year, with maximum savings up to $6,000 per calendar year. Patients' out-of-pocket expenses may vary. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Additional terms and conditions apply. Please see www.vivitrolcopayterms.com for full VIVITROL Co-pay Program Terms and Conditions.

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        The Provider Locator is compiled and published by Alkermes, Inc. as a reference source of demographic and professional information on individual licensed healthcare providers and healthcare provider entities (hereinafter collectively referred to as healthcare provider) in the United States who have experience in the treatment of alcohol dependence and/or opioid dependence. The Provider Locator is searchable by ZIP code or by city and state. Healthcare providers' enrollment and participation in the Provider Locator is voluntary and free of charge and, along with the provider-specific information in the Provider Locator, is based solely on healthcare provider responses. The Provider Locator is provided by Alkermes for use by the medical and dependence treatment communities, potential patients and/or their families in order to find information on, and locate healthcare providers for the treatment of alcohol dependence or opioid dependence. Alkermes is not responsible for, and the Provider Locator is not intended as a tool for, verifying the credentials, expertise, abilities or quality of care of any healthcare provider included in the Provider Locator. Inclusion in the Provider Locator does not imply referral, recommendation or endorsement nor does omission in the Provider Locator imply Alkermes' disapproval. We recommend that, before scheduling an appointment to see any healthcare provider, you research the credentials of the healthcare provider and satisfy yourself that the healthcare provider provides the quality of care desired. You are prohibited from using, downloading, republishing, selling, duplicating, or "scraping" for commercial or any other purpose whatsoever, the Provider Locator or any of the data listings or other information contained therein, in whole or in part, in any medium whatsoever. The information from the Provider Locator is provided on an "AS-IS" basis. Alkermes disclaims all warranties, either express or implied, including but not limited to the implied warranties of merchantability and fitness for particular purpose. Without limiting the foregoing, Alkermes does not warrant or represent that the Provider Locator or any part thereof is accurate or complete. You assume full responsibility for the communications with any healthcare provider you contact through the Provider Locator. Alkermes shall in no event be liable to you or to anyone for any decision made or action taken by you in the reliance on information.

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        At Alkermes, we want to help patients with access to their injection of VIVITROL ® (naltrexone for extended-release injectable suspension). If you need access to injection providers, please contact Vivitrol2gether ® Patient Support Services at 1-800-VIVITROL (1-800-848-4876) for assistance in locating a healthcare provider who is providing injections or click on "Find a Provider" to get a listing of injection providers in your area. Vivitrol2gether can contact injection sites to confirm treatment availability.